N-acetyl cysteine can blunt metabolic and cardiovascular effects via down-regulation of cardiotrophin-1 in rat model of fructose-induced metabolic syndrome

In this study, we investigated the ability of N-acetyl cysteine (NAC) to alleviate metabolic disorders in fructose-induced syndrome (MS) male rats and examine its protective effect on aortic cardiac tissues via influence cardiotrophin-1 (CT-1) expression. NAC (20 mg/kg b.w./day) was administered fructose induced MS animals for 12 weeks. Chronic consumption (20% w/v) increased body weight gain, relative heart weight, systolic blood pressure (SBP), diastolic (DBP), insulin resistance (IR), associated with alterations. Histological immunohistochemical examination revealed stiffness myocardial degeneration fibrosis together CT-1 Treatment improved IR, SBP, DBP, mitigated dyslipidaemia oxidative stress. Additionally, down-regulated expression aorta. These findings demonstrated against through down-regulation animal model.